Description
Your pet must have a current heartworm test result on file with Pet Shot Express in order to be approved for heartworm medication. Please visitone of our clinics to have this test performed annually to protect your pet. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.
 
Uses
Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.
 
Possible Side Effects
When used as prescribed, side effects while using Trifexis are rare. Symptoms of GI distress and skin irritation can occur. Vomiting, diarrhea, lethargy, lack of appetite, and itching and reddening of the skin have been reported. Vomiting may be more likely in puppies under 14 weeks of age. If your dog is truly allergic to Trifexis or to the dying of parasites, she may exhibit symptoms such as facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If your dog experiences any of these symptoms, call your veterinarian or a local emergency veterinarian immediately.
 
Drug & Food Interactions
Always communicate with your veterinarian about any medications, vitamins, or supplements your dog is already taking. Some serious adverse reactions have been documented when used with other spinosad and ivermectin medications simultaneously. No known food interactions have been reported.
 
Precautions
The use of ivermectin at higher than FDA approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, re-dose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
 
Recommended Dosage and Ingredients
Trifexis is a beef-flavored chewable tablet and may be given from your hand, mixed in with food or placed in a treat. Give Trifexis with food for maximum effectiveness. To ensure heartworm prevention, observe your dog for one hour after dosing. If your dog vomits within an hour of administration, re-dose with another full dose.
 
Dosage Chart
Color on
Box
Weight
Range
Strength
Dosage
Rx
MAGENTA
5-10 lbs
140 mg Spinosad &
2.3 mg Milbemycin Oxime
Administer orally
once a month
✓
ORANGE
10.1-20 lbs
270 mg Spinosad &
4.5 mg Milbemycin Oxime
Administer orally
once a month
✓
GREEN
20.1-40 lbs
560 mg Spinosad &
9.3 mg Milbemycin Oxime
Administer orally
once a month
✓
BLUE
40.1-60 lbs
810 mg Spinosad &
13.5 mg Milbemycin Oxime
Administer orally
once a month
✓
BROWN
60.1-120 lbs
1620 mg Spinosad &
27 mg Milbemycin Oxime
Administer orally
once a month
✓
 
Storage Instructions
Store at controlled room temperatures between 68° - 77°F.